Leucoderma and Vitiligo Difference: Causes, Symptoms, Treatment is one of the most searched topics by people experiencing white patches on the skin. Although leucoderma and vitiligo are often used interchangeably, understanding their causes, symptoms, and treatment options is important for proper care. Vitiligo is generally considered an autoimmune skin condition that leads to loss of pigmentation, while leucoderma may also occur due to skin damage, burns, or other external factors.