How does UFE work? Uterine Fibroid Embolization (UFE) is a minimally invasive treatment for uterine fibroids. During the procedure, a specialist guides a small catheter into the blood vessels supplying the fibroids and injects tiny particles to reduce their blood supply. As a result, the fibroids gradually shrink and symptoms such as heavy menstrual bleeding, pelvic pressure, and pain may improve.